Drug Resistant Hypertension - No SIMPLE Way Out

Kidney and Blood Pressure Research

Marcin Ufnal¹  Janusz Skrzypecki¹ 

[1] Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland$$

关键词: Hypertension;    Renal denervation;    Blood pressure;    Heart failure;    Chronic kidney disease;    Sleep apnea syndrome;    Metabolic syndrome;   

DOI  :  10.1159/000368483

来源: S Karger AG

【 摘 要 】

Hypertension poses growing challenge for health policy-makers and doctors worldwide. Recently published results of Symplicity-III trial (HTN-3), the first blinded, randomized, multicenter study on the efficacy of renal denervation for the treatment of resistant hypertension did not show a significant reduction of BP in patients with resistant hypertension 6 months after renal-artery denervation, as compared with controls. In this paper we review clinical and experimental studies on renal denervation. In order to identify causes of inconsistent results in renal denervation studies we look at basic science support for renal denervation and at designs of clinical trials.

【 授权许可】

Unknown