Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury

Kidney and Blood Pressure Research

Bae O.-N.¹  Kim E.-S.¹  Akram M.¹  Kim K.-A.¹  Shin Y.-J.¹  Lee J.S.²  Yu J.-H.¹ 

[1] College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University; $$;EHL Bio, Seoul, Republic of Korea$$

关键词: Nephrotoxicity;    Cisplatin;    Acute kidney injury;    Dendropanax morbifera;   

DOI  :  10.1159/000368466

来源: S Karger AG

【 摘 要 】

Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl₃, EtOAc, n-BuOH, and H₂O fractions. Among these, the CHCl₃ fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.

【 授权许可】

Unknown