Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells

Journal of biosciences

Sun-Joo Oh¹  Woo-Yong Choi²  Chang-Jin Lim3²  Sihyeong Lee3² 

[1] Department of Biological Sciences, Kangwon National University, Chuncheon 200-701, Korea$$;Department of Biochemistry, Kangwon National University, Chuncheon 200-701, Korea$$

关键词: Anti-photoaging;    ginsenoside Rh2;    matrix metalloproteinase;    Panax ginseng C.A. Meyer;    reactive oxygen species;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Ginseng, one of the most widely used herbal medicines, has a wide range of therapeutic and pharmacological applications. Ginsenosides are the major bioactive ingredients of ginseng, which are responsible for various pharmacological activities of ginseng. Ginsenoside Rh2, known as an antitumour ginsenoside, exists as two different stereoisomeric forms, 20(𝑆)-ginsenoside Rh2 [20(𝑆)-Rh2] and 20(𝑅)-ginsenoside Rh2 [20(𝑅)-Rh2]. This work aimed to assess and compare skin anti-photoaging activities of 20(𝑆)-Rh2 and 20(𝑅)-Rh2 in UV-B-irradiated HaCat cells. 20(𝑆)-Rh2, but not 20(𝑅)-Rh2, was able to suppress UV-B-induced ROS production in HaCat cells. Both stereoisomeric forms could not modulate cellular survival and NO level in UV-B-irradiated HaCat cells. Both 20(𝑆)-Rh2 and 20(𝑅)-Rh2 exhibited suppressive effects on UV-B-induced MMP-2 activity and expression in HaCat cells. In brief, the two stereoisomers of ginsenoside Rh2, 20(𝑆)-Rh2 and 20(𝑅)-Rh2, possess skin anti-photoaging effects but possibly in different fashions.

【 授权许可】

Unknown