Altered DNA repair, oxidative stress and antioxidant status in coronary artery disease

Journal of biosciences

Roy D Dinesh¹  A Supriya Simon1²  V Chithra1²  Anoop Vijayan²  T Vijayakumar³ 

[1] Genetika, Centre for Advanced Genetic Studies, Thiruvananthapuram 695 024$$;Department of Biochemistry, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla 689 101$$;Educare Institute of Dental Sciences, Malappuram 676 504$$

关键词: Antioxidant status;    coronary artery disease;    DNA damage;    DNA repair efficiency;    in vitro mutagen sensitivity analysis;    mean break per cell (b/c) values;    oxidative stress;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Coronary artery disease (CAD) is a multifactorial disease caused by the interplay of environmental risk factors with multiple predisposing genes. The present study was undertaken to evaluate the role of DNA repair efficiency and oxidative stress and antioxidant status in CAD patients. Malonaldehyde (MDA), which is an indicator of oxidative stress, and mean break per cell (b/c) values, which is an indicator of decreased DNA repair efficiency, were found to be significantly increased in patients compared to normal controls (𝑃 < 0.05) whereas ascorbic acid and GSH were found to be lower among patients than the control group. It has been found that elevated oxidative stress decreased antioxidant level and decreased DNA repair efficiency can contribute to the development of CAD. This study also showed that high MDA, low ascorbic acid and GSH were significantly associated with high b/c value.

【 授权许可】

Unknown