Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/β2-glycoprotein I complexes in postmenopausal women

Endocrine Journal

Mohsen Ani¹  Mojtaba Panjehpour¹  Elahe Zarean²  Maryam Darabi¹  Ahmad Movahedian¹  Mohammed Rabbani³ 

[1] Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Gynecology and Obstetrics, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran;Department of Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

关键词: Postmenopause;    Antioxidant status;    HRT;    oxLDL/β2GPI complexes;    TAC;   

DOI  :  10.1507/endocrj.K10E-239

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(7)Oxidative stress and consequent oxidized lipoprotein production is thought to play a central role in both the initiation and progression of atherosclerosis.Oxidized low-density lipoprotein (oxLDL)/β2-glycoprotein I (β2GPI) complexes are etiologically important in the development of atherosclerosis.The aim of the present study was to investigate whether long-term treatment with conventional hormone replacement therapy (HRT) in postmenopausal women could affect total serum antioxidant capacity (TAC) and serum levels of oxLDL/β2GPI complexes.A total of 60 normolipidemic postmenopausal women treated with oral estrogen together with progestin therapy for 3 months were selected.TAC and serum levels of oxLDL/β2GPI complexes were measured at the beginning and end of the HRT.HRT led to a significant increase in TAC (15%, P=0.02) and a minor but statistically nonsignificant decrease of oxLDL/β2GPI complexes (3%, P=0.30) when compared with the baseline control levels.There was also no significant association between TAC and oxLDL/β2GPI complexes changes related to HRT.This study indicates that, HRT in postmenopausal women leads to an increase in TAC without an equivalent change in serum levels of oxLDL/β2GPI complexes.It is concluded that beneficial effects of HRT could be explained, at least in part, by improving antioxidant status, but may not be directly associated with a change in oxidized lipoprotein production.

【 授权许可】

Unknown