Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma

Journal of biosciences

Daekyung Kim⁹  Sae-Gwang Park⁸  Su-Kil Seo⁸  Dae-Sung Lee⁵  Seon-Heui Cha⁹  Soo-Jin Heo⁴  Won-Kyo Jung9¹  Sung-Jae Park²  Won Sun Park³  Eun Bo Shim⁶  You-Jin Jeon⁷  Il-Whan Choi6⁸  Jung Sik Choi² 

[1] Department of Marine Life Science, Chosun University, Gwangju 501-759, Republic of Korea$$;Department of Internal Medicine, College of Medicine and Advanced Research Center for Multiple Myeloma, Inje University, Busan 614-735, Republic of Korea$$;Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200-701, Republic of Korea$$;Marine Living Resources Research Department, Korea Ocean Research and Development Institute, Ansan 426-744, Republic of Korea$$;POSTECH Ocean Science and Technology Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea$$;Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 200-701, Republic of Korea$$;Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, Republic of Korea$$;Department of Microbiology, College of Medicine and Advanced Research Center for Multiple Myeloma, Inje University, Busan 614-735, Republic of Korea$$;Marine Bio Research Team, Korea Basic Science Institute, Jeju 690-756, Republic of Korea$$

关键词: Asthma;    free radical;    IgE;    phlorotannins;    Polyopes affinis;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this study was to determine whether an ethanol extract of Polyopes affinis (P.affinis) can inhibit the pathogenesis of T helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergen-specific immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic disorders such as allergic asthma.

【 授权许可】

Unknown