Molecular mechanism of insulin resistance

Journal of biosciences

Debleena Dey²  Samir Bhattacharya1¹  Sib Sankar Roy² 

[1] Cellular and Molecular Endocrinology Laboratory, Department of Zoology, School of Life Science, Visva-Bharati (A Central University), Santiniketan 731 235, India$$;Molecular Endocrinology Laboratory, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India$$

关键词: Fatty acid;    insulin receptor;    insulin resistance;    insulin signalling;    novel PKC;    type 2 diabetes;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCε causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.

【 授权许可】

Unknown