Modulation of polymorphonuclear leukocytes function by incubation with human serum from oxidant-challenged individuals

Journal of biosciences

A Tamir²  T Machamid¹  A Tabak³  E Hoffer1³  Y Lerman²  Y Baum³ 

[1] Kupat Holim Clalit, Occupational Medicine, Faculty of Medicine, Technion, Haifa 31096, Israel$$;Occupational Health Center, Kupat Holim Clalit and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel$$;Israel Poison Information Center, Rambam Medical Center Haifa 31096, Israel$$

关键词: Polymorphonuclear leukocytes;    smoking;    superoxide release;    welders;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Polymorphonuclear leukocytes (PMN) from healthy donors were tested for stimulated release of superoxide anions after being incubated with serum of welders and of a group of unexposed individuals. These two groups were further subdivided either according to age or to smoking habits. The experiments showed that stimulated superoxide production from PMN was inhibited (𝑃 < 0.05) by serum from young smokers as compared to that of young nonsmokers, both from the unexposed group. Incubation of PMN with serum from elderly nonsmoking individuals decreased superoxide production as compared to incubation with serum from young nonsmoking individuals, both from the unexposed group. A decrease in superoxide production by incubation with serum of welders as compared to that of unexposed individuals was significant only when the comparison was carried out between the young, non-smoking subgroups. These findings suggest that age, smoking, and exposure to oxidants induce appearance in serum of factors that affect the PMN function.

【 授权许可】

Unknown