Clinical and Experimental Rheumatology | |
Chlamydophila psittaci subclinical infection in chronic polyarthritis. | |
Piercarlo Sarzi-Puttini1  Pia Morassi1  Luca Quartuccio1  Raffaele Pellerito1  Sandra Lombardi1  Salvatore De Vita1  Francesco Curcio1  Elisa Pasini1  Domenico Biasi1  Riccardo Dolcetti1  Maurizio Benucci1  Cinzia Fabro1  Elena Pontarini1  Martina Fabris1  | |
关键词: Chlamydophila psittaci; Autoimmunity; Chlamydophila psittaci; Rheumatoid arthritis; Chlamydophila psittaci; pathogenesis; rheumatoid factor; anti-citrullinated peptides antibodies; | |
DOI : | |
学科分类:医学(综合) | |
来源: Pacini Editore SpA | |
【 摘 要 】
OBJECTIVES: Recent evidence indicates that Chlamydophila psittaci (Cp) may establish chronic infections, which may promote autoimmunity and/or B cell lymphoproliferation. METHODS: The presence of a subclinical Cp infection was investigated in 293 patients with chronic inflammatory polyarthritis, including 175 patients with rheumatoid factor (RF)-positive and/or anti-CCP-positive rheumatoid arthritis (RA) and 118 with seronegative polyarthritis (46 RF-negative/anti-CCP-negative RA, 36 psoriatic arthritis and 36 undifferentiated spondyloarthritis). One hundred and eighty-five healthy controls were also investigated. The presence of Cp infection was assessed in peripheral blood mononuclear cells using several PCR protocols targeting different regions of the Cp genome (16S-23S spacer rRNA, OMP-A, and Gro-EL). The DNA of other Chlamydia species (C. Pneumoniae and C. Trachomatis) was also investigated. Amplicons were sequenced to confirm the specificity of PCR products. RESULTS: The presence of a subclinical chronic Cp infection was observed in a significantly higher percentage of patients with chronic polyarthritis (38/293; 13%) compared to healthy controls (1/185, 0.5%; OR=27.4, 95%CI:3.73-201.6, p
【 授权许可】
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RO201912020417332ZK.pdf | 166KB | download |