HBZ interacts with JunD and stimulates its transcriptional activity

FEBS Letters

Hivin, Patrick¹  Mesnard, Jean-Michel¹  Basbous, Jihane¹  Devaux, Christian¹  Thébault, Sabine¹ 

[1] Laboratoire Infections Rétrovirales et Signalisation Cellulaire, CNRS/UM I UMR 5121/IFR 122, Institut de Biologie, 4 Bd Henri IV, CS 89508, 34960 Montpellier Cedex 2, France

关键词: Human T-cell leukemia virus type I;    Basic leucine zipper factor;    Human T-cell leukemia virus type I basic leucine zipper;    Activator protein-1;    JunD;    HTLV-I;    human T-cell leukemia virus type I;    ATL;    adult T-cell leukemia;    CREB-2;    cAMP response element binding protein-2;    AP-1;    activator protein-1;    bZIP;    basic leucine zipper;    HBZ;    HTLV-I bZIP factor;   

DOI  :  10.1016/S0014-5793(04)00225-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human T-cell leukemia virus type I (HTLV-I) bZIP factor (HBZ) is a viral basic leucine zipper protein that was originally described as a partner of cAMP response element binding protein-2 and as a repressor of HTLV-I viral transcription. In addition, HBZ is able to interact with the activator protein-1 (AP-1) transcription factors c-Jun and JunB, the interaction with c-Jun leading to a transcriptional repression of AP-1-regulated genes. Here we show that HBZ also interacts with JunD in vitro and in vivo, and that this association occurs via the bZIP domain of the two proteins. Moreover, we show that HBZ can activate JunD-dependent transcription and that its amino-terminus is required.

【 授权许可】

Unknown