Increased protein tyro sine‐phosphorylation in primary T‐cells transduced with Tax l of Human T‐cell leukemia virus type I

FEBS Letters

Ono, Hiroaki²  Shimotohno, Kunitada²  Akagi, Tsuyoshi²  Sasaki, Terukatsu¹ 

[1] Department of Biochemistry, Cancer Research Institute, Sapporo Medical College, S.1, W17, Sapporo 060, Japan;Virology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan

关键词: Human T-cell leukemia virus type I;    Taxl;    Cdc2;    Tyrosine phosphorylation;    src-family tyrosine kinase;    Lyn;   

DOI  :  10.1016/0014-5793(94)01390-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein tyrosine-phosphorylation in primary human T-cells transduced with Taxi of Human T -cell leukemia virus type I was investigated. In comparison with control T-cells, the level of protein tyrosine-phosphorylation after stimulation with anti-CD3 antibody increased significantly in Tax1-transduced T-cells. This enhancement in tyrosine-phosphorylation possibly accounted for the augmented proliferative response of these cells, which has been reported previously

【 授权许可】

Unknown