The cAMP response element binding protein‐2 (CREB‐2) can interact with the C/EBP‐homologous protein (CHOP)

FEBS Letters

Mesnard, Jean-Michel¹  Basbous, Jihane¹  Devaux, Christian¹  Koffi, Joseph Aman¹  Thébault, Sabine¹  Gaudray, Gilles¹  Gachon, Frédéric¹ 

[1] Laboratoire Infections Rétrovirales et Signalisation Cellulaire, CNRS EP 2104/Université Montpellier I, Institut de Biologie, 4 Bd Henri IV, 34060 Montpellier, France

关键词: Basic leucine zipper factor;    cAMP response element binding protein-2;    C/EBP-homologous protein;    cAMP response element site;    Human T-cell leukemia virus type I;    CREB;    cAMP response element binding protein;    ATF;    activating transcription factor;    bZIP;    basic leucine zipper;    HTLV-I;    human T-cell leukemia virus type I;    C/EBP;    CCAAT/enhancer binding protein;    CHOP;    C/EBP-homologous protein;    GADD;    growth arrest- and DNA damage-inducible protein;    TxRE;    Tax-responsive element;   

DOI  :  10.1016/S0014-5793(01)02646-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

cAMP response element binding protein-2 (CREB-2) is a basic leucine zipper (bZIP) factor that was originally described as a repressor of CRE-dependent transcription but that can also act as a transcriptional activator. Moreover, CREB-2 is able to function in association with the viral Tax protein as an activator of the human T-cell leukemia virus type I (HTLV-I) promoter. Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription. Cotransfection of CHOP with CREB-2 results in decreased activation driven by the cellular CRE motif or the HTLV-I proximal Tax-responsive element, confirming that CREB-2 and CHOP can interact with each other in vivo.

【 授权许可】

Unknown