Ceramide‐1‐phosphate: a novel regulator of cell activation

FEBS Letters

Gómez-Muñoz, Antonio¹ 

[1] Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48080 Bilbao, Spain

关键词: Apoptosis;    cell proliferation;    Ceramide-1-phosphate;    Sphingolipid;    Sphingosine-1-phosphate;    Sphingomyelinase;    C2-ceramide;    N-acetylsphingosine;    C8-ceramide;    N-octanoylsphingosine;    Cer-1-P;    ceramide-1-phosphate;    ERK;    extracellular signal-regulated kinase;    MAPK;    mitogen-activated protein kinase;    PA;    phosphatidate;    PKC;    protein kinase C;    PLA2;    phospholipase A2;    PLD;    phospholipase D;    SM;    sphingomyelin;    Sph-1-P;    sphingosine-1-phosphate;   

DOI  :  10.1016/S0014-5793(04)00211-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ceramide-1-phosphate (Cer-1-P) is emerging as a novel bioactive sphingolipid. It is formed by phosphorylation of ceramide catalyzed by ceramide kinase, and has been implicated in different cellular processes. Cer-1-P is mitogenic for fibroblasts, blocks apoptosis in macrophages, controls phagocytosis in neutrophils, and mediates inflammatory responses. Only recently have we started to uncover the signaling pathways that are affected by Cer-1-P. Recent work has demonstrated that cytosolic phospholipase A₂ and acid sphingomyelinase are direct intracellular targets of Cer-1-P, and that it may also induce phosphorylation of extracellular signal-regulated kinase-2 and calcium mobilization. These actions of Cer-1-P seem to be cell type-specific.

【 授权许可】

Unknown