Mitochondrial effectors in caspase‐independent cell death

FEBS Letters

Susin, Santos A²  Lorenzo, Hans K¹ 

[1] INSERM U542, 14 Av. Paul Vaillant Couturier, 94803 Villejuif, France;Groupe Apoptose et Système Immunitaire, Institut Pasteur, CNRS-URA 1961, 25 rue du Dr. Roux, 75015 Paris, France

关键词: Apoptosis-inducing factor;    Apoptosis;    Caspase-independent cell death;    Endonuclease G;    Omi/HtrA2;    Mitochondrion;    AIF;    apoptosis-inducing factor;    AMID;    AIF-homologous mitochondrion-associated inducer of death;    EndoG;    endonuclease G;    HSpin1;    human homolog of the Drosophila spin gene product;    HtrA2;    high temperature requirement protein A2;    PRG3;    p53-responsive gene 3;    Smac/DIABLO;    second mitochondria-derived activator of caspase/direct IAP binding protein with low pI;    WOX;    WW domain-containing oxidoreductase;   

DOI  :  10.1016/S0014-5793(03)01464-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Activation of caspases is recognized as a key element in the apoptotic process. However, new evidence is drawing attention to the emergent role of cell death pathways where caspases are not involved. Recent advances in the molecular understanding of these new ways to die, called caspase-independent, have revealed that mitochondria play an important role via the release of proapoptotic proteins. The purpose of this review is to integrate, from a biological and structural point of view, the most recent advances in the knowledge of the main mitochondrial proapoptotic proteins involved in this cell death cascade. The origin of programmed cell death is discussed through these strongly conserved effectors.

【 授权许可】

Unknown