Microcystin‐LR and okadaic acid‐induced cellular effects: a dualistic response

FEBS Letters

Gehringer, Michelle M¹ 

[1] School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia

关键词: Microcystin;    Okadaic acid;    Protein phosphatase;    Apoptosis;    Tumorigenesis;   

DOI  :  10.1016/S0014-5793(03)01447-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Microcystins, potent heptapeptide hepatotoxins produced by certain bloom-forming cyanobacteria, are strong protein phosphatase inhibitors. They covalently bind the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A), thereby influencing regulation of cellular protein phosphorylation. The paralytic shellfish poison, okadaic acid, is also a potent inhibitor of these PPs. Inhibition of PP1 and PP2A has a dualistic effect on cells exposed to okadaic acid or microcystin-LR, with both apoptosis and increased cellular proliferation being reported. This review summarises the existing data on the molecular effects of microcystin-LR inhibition of PP1 and PP2A both in vivo and in vitro, and where possible, compares this to the action of okadaic acid.

【 授权许可】

Unknown