Bone marrow‐derived cells contribute to lung regeneration after elastase‐induced pulmonary emphysema

FEBS Letters

Kubo, Hiroshi²  Ishizawa, Kota²  Suzuki, Takashi³  Sasaki, Hidetada²  Ueda, Shinsaku¹  Kobayashi, Seiichi²  Numasaki, Muneo²  Yamada, Mitsuhiro² 

[1]Miyagi Cancer Centre, Natori 989-1239, Japan

[2]Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980-8574, Japan

[3]Department of Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980-8574, Japan

关键词: Bone marrow;    Progenitor cell;    Pulmonary emphysema;    Granulocyte colony-stimulating factor;    Regeneration;    ATRA;    all-trans retinoic acid;    BMC;    bone marrow-derived cell;    G-CSF;    granulocyte colony-stimulating factor;    GFP;    green fluorescent protein;    Sca-1;    stem cell antigen-1;    Flk-1;    fetal liver kinase-1;    Lm;    mean linear intercept;   

DOI  :  10.1016/S0014-5793(03)01399-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

All-trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase-induced emphysema were treated with ATRA, granulocyte colony-stimulating factor (G-CSF), or a combination of both. ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration.

【 授权许可】

Unknown