In vivo p53 function is indispensable for DNA damage‐induced apoptotic signaling in Drosophila

FEBS Letters

Lee, Jun Hee²  Park, Jeehye²  Chung, Jongkyeong²  Lee, Eunji²  Kim, Euysoo²  Kim, Jaeseob¹ 

[1] Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong, Taejon 305-701, South Korea;National Creative Research Initiatives Center for Cell Growth Regulation, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea

关键词: Apoptosis;    p53;    Genomic stability;    Cell cycle checkpoint;    Reaper;    Caspase;   

DOI  :  10.1016/S0014-5793(03)00771-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

p53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation-induced apoptosis and reaper induction. These results indicate that Dmp53 is a central component of DNA damage-dependent apoptotic signaling.

【 授权许可】

Unknown