Macropexophagy in Hansenula polymorpha: facts and views

FEBS Letters

Kiel, Jan A.K.W¹  Veenhuis, Marten¹  Komduur, Janet A¹  van der Klei, Ida J¹ 

[1] Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

关键词: Methylotrophic yeast;    Autophagy;    Nitrogen limitation;    Peroxisome;    Peroxin;    Cvt;    cytoplasm to vacuole targeting;    AO;    alcohol oxidase;    PDD;    peroxisome degradation-deficient;    Vps;    vacuolar protein sorting;    Apg;    autophagy;    End;    endocytosis;    Sc;    Saccharomyces cerevisiae;    Hp;    Hansenula polymorpha;    Pp;    Pichia pastoris;    PtdIns;    phosphatidylinositol;    Pex;    peroxisome biogenesis;    PAS;    pre-autophagosomal structure;    PE;    phosphatidylethanolamine;   

DOI  :  10.1016/S0014-5793(03)00794-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hallmark of eukaryotic cells is compartmentalization of distinct cellular functions into specific organelles. This necessitates the cells to run energetically costly mechanisms to precisely control maintenance and function of these compartments. One of these continuously controls organelle activity and abundance, a process termed homeostasis. Yeast peroxisomes are favorable model systems for studies of organelle homeostasis because both the proliferation and degradation of these organelles can be readily manipulated. Here, we highlight recent achievements in regulation of peroxisome turnover in yeast, in particular Hansenula polymorpha, with a focus on directions of future research.

【 授权许可】

Unknown