MHC class II engagement inhibits CD99‐induced apoptosis and up‐regulation of T cell receptor and MHC molecules in human thymocytes and T cell line

FEBS Letters

Choi, Yoon-La²  Kim, Min Kyung²  Bae, Young Mee³  Woo, Sang Kyu¹  Choi, Eun Young²  Park, Seong Hoe²  Kim, Seok-Hyung²  Park, Won Seo³ 

[1] DiNonA, Inc., 65 Umyeon-dong, Seocho-gu, Seoul 137-140, South Korea;Department of Pathology, College of Medicine, Seoul National University, Yongun-dong 28, Chongro-gu, Seoul 110-799, South Korea;Department of Pathology, Kangwon National University College of Medicine, 192-1 Hyoja 2-dong, Chunchon, Kangwon-do 200-701, South Korea

关键词: Major histocompatibility complex class II;    CD99;    T cell receptor;    Apoptosis;    Thymocyte;    Selection;    MHC;    major histocompatibility complex;    TCR;    T cell receptor;    PI;    propidium iodide;    APC;    antigen-presenting cell;   

DOI  :  10.1016/S0014-5793(03)00567-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Major histocompatibility complex (MHC) class II surface levels on thymocytes increase after CD99 ligation. The functional implication of the up-regulated MHC class II was assessed by engaging MHC class II on CD99-ligated cells. MHC class II engagement down-modulated surface levels of T cell receptor and MHC molecules, and inhibited apoptosis of CD99-ligated thymocytes and CEM tumor cells, antagonistic effects on the previously reported CD99 functions. The results were reproducible regardless of the order of ligation of MHC class II and CD99. We suggest that signaling via MHC class II on CD99-engaged cells might be involved in the thymic maturation process by damping CD99 ligation effects.

【 授权许可】

Unknown