Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans‐10,cis‐12‐linoleic acid

FEBS Letters

Degrace, Pascal¹  Clouet, Pierre¹  Gresti, Joseph¹  Demizieux, Laurent¹  Sébédio, Jean-Louis²  Chardigny, Jean-Michel² 

[1] UPRES Lipides et Nutrition EA2422, Université de Bourgogne, 6 bd Gabriel, 21000 Dijon, France;INRA, Unité de Nutrition Lipidique, 17 rue Sully, 21034 Dijon Cedex, France

关键词: Liver steatosis;    Conjugated linoleic acid;    Lipoprotein;    Triacylglycerol;    Fatty acid;    Low-density lipoprotein receptor;    CLA;    conjugated linoleic acid;    DGAT;    diacylglycerol acyltransferase;    FA;    fatty acid;    HL;    hepatic lipase;    LDL-R;    low-density lipoprotein receptor;    LPL;    lipoprotein lipase;    PPAR;    peroxisome proliferator-activated receptor;    RT-PCR;    reverse transcriptase-polymerase chain reaction;    SREBP;    sterol regulatory element binding protein;    TAG;    triacylglycerol;    VLDL;    very low-density lipoprotein;   

DOI  :  10.1016/S0014-5793(03)00610-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Conjugated linoleic acids (CLA) have recently been recognized to reduce body fat and plasma lipids in some animals. This study demonstrated that the steatosis accompanying the fat loss induced by trans-10,cis-12-C_18:2 (CLA2) and not cis-9,trans-11-C_18:2 (CLA1) isomer in C57BL/6j mice was not due to an alteration of the liver lipoprotein production that was even increased. The 3-fold decrease in plasma triacylglycerol contents and the induction of mRNA expression of low-density lipoprotein receptors concomitantly observed in CLA2-fed mice suggested an increase in the lipoprotein clearance at the level of the liver itself. CLA1 feeding produced similar but attenuated effects on triglyceridaemia only.

【 授权许可】

Unknown