The ins and outs of leptin receptor activation

FEBS Letters

Lavens, Delphine¹  Peelman, Frank¹  Eyckerman, Sven¹  Vandekerckhove, Joël¹  Zabeau, Lennart¹  Tavernier, Jan¹ 

[1] The Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research (VIB9), Ghent University, Faculty of Medicine and Health Sciences, Baertsoenkaai 3, B-9000 Ghent, Belgium

关键词: Leptin;    Leptin receptor;    Receptor clustering;    Signal transduction;    CRH;    cytokine receptor homology;    FN III;    fibronectin type III;    G-CSF;    granulocyte colony-stimulating factor;    gp130;    glycoprotein 130;    Grb-2;    growth receptor-bound-2;    Ig;    immunoglobulin;    IL;    interleukin;    IRS;    insulin receptor substrate;    JAK;    Janus kinase;    LIF;    leukemia inhibitory factor;    LR;    leptin receptor;    MAPK;    mitogen-activated protein kinase;    OSM;    oncostatin M;    PI3K;    phosphatidylinositol 3-kinase;    PTP1B;    phosphotyrosine phosphatase 1B;    SHP-2;    SH2-containing phosphatase-2;    SOCS;    suppressor of cytokine signaling;    STAT;    signal transducer and activator of transcription;   

DOI  :  10.1016/S0014-5793(03)00440-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The adipocyte-derived hormone leptin signals the status of body energy stores by activating its receptor in hypothalamic nuclei. In contrast to the initial expectations, leptin treatment of human obesity was largely unsuccessful. One explanation for this is the marked leptin resistance, which likely operates in part at the receptor level. The leptin receptor is a member of the class I cytokine receptor family, which uses the Janus kinase/signal transducer and activator of transcription pathway as a major signaling route. In this review, we focus on the molecular mechanisms underlying leptin receptor activation. Different modes of leptin-induced clustering of the ectodomains and the subsequent signaling events will be discussed.

【 授权许可】

Unknown