Metabolic efficiency of liver mitochondria in rats with decreased thermogenesis

FEBS Letters

Iossa, Susanna¹  Crescenzo, Raffaella¹  Mollica, Maria Pia¹  Botta, Monica¹  Lionetti, Lill๠ Liverini, Giovanna¹ 

[1] Dipartimento di Fisiologia Generale ed Ambientale, Università ‘Federico II’ of Naples, Via Mezzocannone 8, I-80134 Naples, Italy

关键词: Mitochondrial efficiency;    Fasting;    Basal proton leak;    Palmitate-induced uncoupling;    ANT;    adenine nucleotide translocator;    BAT;    brown adipose tissue;    CAT;    carboxyatractyloside;    COX;    cytochrome oxidase;    FFA;    free fatty acids;    ROS;    reactive oxygen species;    T3;    triiodothyronine;   

DOI  :  10.1016/S0014-5793(03)00490-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have studied changes in hepatic mitochondrial efficiency induced by 24-h fasting or acclimation at 29°C, two conditions of reduced thermogenesis. Basal and palmitate-induced proton leak, which contribute to mitochondrial efficiency, are not affected after 24-h fasting, when serum free triiodothyronine decreases significantly and serum free fatty acids increase significantly. In rats at 29°C, in which serum free triiodothyronine and fatty acids decrease significantly, basal proton leak increases significantly, while no variation is found in palmitate-induced proton leak. The present results indicate that mitochondrial efficiency in the liver is not related to a physiological decrease in whole body thermogenesis.

【 授权许可】

Unknown