Identification of cDNAs from Japanese pufferfish (Fugu rubripes) and Atlantic salmon (Salmo salar) coding for homologues to tetrapod prion proteins

FEBS Letters

Hoffmann, Rudolf³  Baier, Michael¹  Oidtmann, Birgit³  Holtkamp, Nikola²  Simon, Dietrich¹ 

[1] Project Neurodegenerative Diseases, Robert-Koch-Institute, Nordufer 20, 13353 Berlin, Germany;Institute of Neuropathology, Humboldt University, Augustenburgerplatz 1, 13353 Berlin, Germany;Institute of Zoology, Fish Biology and Fish Diseases, Veterinary Faculty, University of Munich, Kaulbachstr. 37, 80539 Munich, Germany

关键词: Atlantic salmon;    Fugu rubripes;    Prion;   

DOI  :  10.1016/S0014-5793(03)00149-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon (Salmo salar) and Japanese pufferfish (Fugu rubripes), which were termed ‘similar to PrPs’ (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod PrPs. In addition, two stPrPs were shown to be highly expressed in brain tissue. None of the so far identified PrP-homologues of fish resembles doppel. Hence, the duplication of the PrP gene, which generated doppel, may have occurred not in fish but later in the tetrapod lineage. The identification of fish PrPs provides a basis to address concerns about a possible susceptibility of fish to prion infections.

【 授权许可】

Unknown