Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes 1

FEBS Letters

Clark, Melody²  Cottage, Amanda²  Elgar, Greg²  Bishop, Martin²  Umrania, Yagnesh²  Wheller, Denis³  Hawker, Kelvin¹ 

[1] MRC Growth Factors Group, MRC Centre, Hills Road, Cambridge CB2 2QH, UK;MRC HGMP Resource Centre, Hinxton, Cambridge CB10 1SB, UK;Faculty of Built and Environmental Science, Anglia Polytechnic University, East Road, Cambridge CB1 1PT, UK

关键词: Hepatocyte growth factor/receptor;    Plasminogen;    Oncogene;    Genomic sequence;    Fugu rubripes;   

DOI  :  10.1016/S0014-5793(99)00011-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Plasminogen related growth factors (PRGFs) and their receptors play major roles in embryogenesis, tissue regeneration and neoplasia. In order to investigate the complexity and evolution of the PRGF receptor family we have cloned and sequenced three receptors for PRGFs in the teleost fish Fugu rubripes, a model vertebrate with a compact genome. One of the receptor genes isolated encodes the orthologue of mammalian MET, whilst the other two may represent Fugu rubripes orthologues of RON and SEA. This is the first time three PRGF receptors have been identified in a single species.

【 授权许可】

Unknown