FEBS Letters | |
Cyclin destruction in mitosis: a crucial task of Cdc20 | |
Irniger, Stefan1  | |
[1] Institute of Microbiology and Genetics, Georg-August-University, Grisebachstr. 8, D-37077 Göttingen, Germany | |
关键词: Anaphase-promoting complex; Clb2; Cyclin B; Mitotic exit; Ubiquitin-dependent proteolysis; | |
DOI : 10.1016/S0014-5793(02)03657-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin-dependent kinases. Cyclin proteolysis is triggered by the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit complex which contains ubiquitin ligase activity. Recent data in yeast demonstrated that a partial degradation of the mitotic cyclin Clb2, mediated by APC/C and its activator protein Cdc20, is essential and sufficient for the mitotic exit. Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020312463ZK.pdf | 208KB | download |