Biological effects of group IIA secreted phosholipase A2

FEBS Letters

Sánchez Crespo, Mariano¹  Nieto, Marı́a Luisa¹  Fuentes, Lucı́a¹  Hernández, Marita¹ 

[1] Instituto de Biologı́a y Genética Molecular, Consejo Superior de Investigaciones Cientı́ficas, Facultad de Medicina, 47005 Valladolid, Spain

关键词: Astrocyte;    Atherosclerosis;    Inflammation;    Lipid mediator;    Leukocyte;    Protein kinase;    sPLA2-IIA;    group IIA secreted phospholipase A2;    cPLA2;    cytosolic phospholipase A2;    ERK;    extracellular signal-regulated kinase;    JNK;    c-Jun N-terminal kinase;    MAP kinase;    mitogen-activated protein kinase;    MEK;    MAP kinase kinase of the MAP/ERK group;   

DOI  :  10.1016/S0014-5793(02)03401-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Group IIA secreted phospholipase A₂ (sPLA₂-IIA) is the most abundant element in human tissues of a large family of low molecular weight phospholipases A₂, which shows properties different from those displayed by the cytosolic phospholipase A₂ involved in the release of arachidonic acid. sPLA₂-IIA behaves as a ligand for a group of receptors inside the C-type multilectin mannose receptor family and also interacts with heparan sulfate proteoglycans such as glypican, the dermatan/chondroitin sulfate-rich decorin, and the chondroitin sulfate-rich versican, thus being able to internalize to specific compartments within the cell and producing biological responses. This review provides a short summary of the biological actions of sPLA₂-IIA on intracellular signaling pathways.

【 授权许可】

Unknown