Toxicity evolution of Vipera aspis aspis venom: identification and molecular modeling of a novel phospholipase A2 heterodimer neurotoxin 1

FEBS Letters

Robbe-Vincent, Annie²  Choumet, Valérie²  De Haro, Luc¹  Maroun, R.C²  Jan, Virginie² 

[1] Centre Anti-poisons, Hôpital Salvator, 249 bvd Sainte Marguerite, 13274 Marseille Cedex 9, France;Unité des Venins, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France

关键词: Evolution;    Interbreeding;    Neurotoxin;    Phospholipase A2;    Snake venom;    Three-dimensional structure;   

DOI  :  10.1016/S0014-5793(02)03205-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report the simultaneous presence of two phospholipase A₂ (PLA₂) neurotoxins in the venom of Vipera aspis aspis, the first such observation. One is monomeric and identical to ammodytoxin B of Vipera ammodytes ammodytes. Its presence may result from gene flux after interbreeding between V. aspis aspis and V. ammodytes ammodytes. The second, a novel heterodimer named vaspin, is very similar to vipoxin of Vipera ammodytes meridionalis and to PLA₂-I of Vipera aspis zinnikeri. It may result from expression of preexisting genes, the acidic subunit evolving from an ancestor common to ammodytin I2 from V. ammodytes ammodytes, which we also found in V. aspis aspis.

【 授权许可】

Unknown