The physiological role of dehydroascorbic acid

FEBS Letters

Wilson, John X¹ 

[1] Department of Physiology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1

关键词: Dehydroascorbic acid;    Ascorbic acid;    Transport;    Oxidative stress;    Inflammation;    Sepsis;    Diabetes;    AA;    ascorbic acid;    DHA;    dehydroascorbic acid;    IFNγ;    interferon-γ;   

DOI  :  10.1016/S0014-5793(02)03167-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dehydroascorbic acid (DHA) is abundant in the human diet and also is generated from vitamin C (ascorbic acid, AA) in the lumen of the gastrointestinal tract. DHA is absorbed from the lumen of the small intestine and reduced to AA, which subsequently circulates in the blood. Utilization of AA as an antioxidant and enzyme cofactor causes its oxidation to DHA in extracellular fluid and cells. DHA has an important role in many cell types because it can be used to regenerate AA. Both physiological (e.g. insulin, insulin-like growth factor I, cyclic AMP) and pathological (e.g. oxidative stress, diabetes, sepsis) factors alter the transport and metabolic mechanisms responsible for this DHA recycling.

【 授权许可】

Unknown