Transposon‐like Correia elements: structure, distribution and genetic exchange between pathogenic Neisseria sp

FEBS Letters

Buisine, Nicolas²  Tang, Christoph M¹  Chalmers, Ronald² 

[1] Department of Infectious Diseases, Imperial College of Sciences, Technology and Medicine, The Flowers Building, Armstrong Road, London SW7 2AZ, UK;Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK

关键词: Pathogen;    Virulence;    Polymorphism;    Genetic exchange;    Horizontal transfer;    Integration host factor;    IHF;    integration host factor;    SBI;    strand bias index;    SRE;    simple repetitive element;    N.m.;    Neisseria meningitidis;    N.g.;    Neisseria gonorrhoeae;   

DOI  :  10.1016/S0014-5793(02)02882-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Correia elements are a prominent feature of all four Neisseria genome sequences. We report an in silico analysis of the structure and genomic distribution of these elements and some preliminary biochemical data. Correia elements fall into four major families, distinguished by a 50 bp internal deletion and five point mutations. The elements resemble a transposon with 25 bp inverted repeats and a TA duplication at the target site. Within the element there is a functional integration host factor binding site. The genomic distribution of Correia elements is essentially random except for some small Correia-less regions apparently acquired by horizontal transfer. Phylogenetic analysis suggests that their presence predates the divergence of Neisseria meningitidis and Neisseria gonorrhoeae.

【 授权许可】

Unknown