TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF‐κB activation

FEBS Letters

Leonardi, Antonio¹  Liguoro, Domenico³  Stilo, Romania⁴  Di Jeso, Bruno⁵  Formisano, Luigi²  Vito, Pasquale⁴ 

[1] Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy;Dipartimento di Neuroscienza, Università degli Studi di Napoli Federico II, Napoli, Italy;Centro di Endocrinologia ed Oncologia Sperimentale, Napoli, Italy;BioGeM Consortium, Napoli, Italy;Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze MFN, Università degli Studi di Lecce, Lecce, Italy

关键词: Caspase recruitment domain;    Protein;    Nuclear factor-κB;    Apoptosis;    p53;    DRAL;   

DOI  :  10.1016/S0014-5793(02)02869-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-κB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-κB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-κB activity, expression of DRAL results in enhancement of NF-κB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-κB transcription factor.

【 授权许可】

Unknown