Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)

FEBS Letters

Azzi, Angelo¹  Ricciarelli, Roberta²  Zingg, Jean-Marc¹ 

[1] Institute of Biochemistry and Molecular Biology, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland;Dipartimento di Medicina Sperimentale, Università di Genova, Via L.B. Alberti 2, 16132 Genoa, Italy

关键词: α-Tocopherol;    Non-antioxidant mechanism;    Protein kinase C;    Cell proliferation;    Gene expression;    Platelet aggregation;    Oxygen burst;    TAP;    tocopherol associated protein;    AVED;    ataxia with vitamin E deficiency;    α-TTP;    α-tocopherol transfer protein;    PKC;    protein kinase C;    PP2A;    protein phosphatase 2A;   

DOI  :  10.1016/S0014-5793(02)02706-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

α-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by α-tocopherol was first described by our group. Later, α-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. α-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.

【 授权许可】

Unknown