The flavonoid baicalin inhibits superantigen‐induced inflammatory cytokines and chemokines

FEBS Letters

Li, Bao Qun¹  Krakauer, Teresa²  Young, Howard A.³ 

[1] Intramural Research Support Program, SAIC Frederick, Frederick, MD 21702, USA;Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702-5011, USA;Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, MD 21702, USA

关键词: Immunosuppression;    Superantigen;    Cytokine and chemokine;    Baicalin;    Flavonoid;    TSST-1;    staphylococcal toxic shock syndrome toxin 1;    SEA and SEB;    staphylococcal enterotoxin A and B;    BA;    baicalin;    IL;    interleukin;    MCP-1;    monocyte chemotactic protein 1;    MIP-1;    macrophage inflammatory protein 1;    TNFα;    tumor necrosis factor α;    IFNγ;    interferon γ;    PBMC;    peripheral blood mononuclear cells;   

DOI  :  10.1016/S0014-5793(01)02584-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Excessive release of proinflammatory cytokines mediates the toxic effect of superantigenic staphylococcal exotoxins (SE). Baicalin, a flavone isolated from the Chinese herb Scutellaria baicalensis Georgi and used in China to treat infectious diseases, inhibited SE-stimulated T-cell proliferation (by 98%) and production of interleukin 1β, interleukin 6, tumor necrosis factor, interferon γ, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)-1α, and MIP-1β mRNA and protein by human peripheral blood mononuclear cells. These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens.

【 授权许可】

Unknown