Different effects of the Ca2+‐binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2

FEBS Letters

Nandi, Sumon¹  Artman, Michael¹  Rudy, Bernardo²  Nakamura, Tomoe Y.¹  Pountney, David J.¹  Coetzee, William A.¹ 

[1] Pediatric Cardiology (TH519), NYU School of Medicine, 560 First Avenue, New York, NY 10016, USA;Physiology and Neurosciences, NYU School of Medicine, 560 First Avenue, New York, NY 10016, USA

关键词: Kv4-subunit;    K+ channel-interacting protein 1;    Regulatory subunit;    Molecular diversity;    Potassium channel;    KChIP;    K+ channel-interacting protein;   

DOI  :  10.1016/S0014-5793(01)02560-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Ca²⁺-binding protein, K⁺ channel-interacting protein 1 (KChIP1), modulates Kv4 channels. We show here that KChIP1 affects Kv4.1 and Kv4.2 currents differently. KChIP1 slows Kv4.2 inactivation but accelerates the Kv4.1 inactivation time course. Kv4.2 activation is shifted in a hyperpolarizing direction, whereas a depolarizing shift occurs for Kv4.1. On the other hand, KChIP1 increases the current amplitudes and accelerates recovery from inactivation of both currents. An involvement of the Kv4 N-terminus in these differential effects is demonstrated using chimeras of Kv4.2 and Kv4.1. These results reveal a novel interaction of KChIP1 with these two Kv4 members. This represents a mechanism to further increase the functional diversity of K⁺ channels.

【 授权许可】

Unknown