Endocytosis and signaling cascades: a close encounter

FEBS Letters

Cavalli, Valeria¹  Corti, Michela¹  Gruenberg, Jean¹ 

[1] Department of Biochemistry, University of Geneva, Sciences II, 30 quai Ernest Ansermet, 1211 Geneva-4, Switzerland

关键词: Signal transduction;    Traffic;    Rab protein;    Phosphoinositide;    Growth factor;    Clathrin;    Actin;    FYVE protein;    PI;    phosphatidylinositol;    PI(3)P;    phosphatidylinositol-3-phosphate;    PI(3;    5)P2;    phosphatidylinositol-3;    5-bisphosphate;    PLD;    phospholipase D;    GAP;    GTPase-activating protein;    MVB;    multivesicular body;    ECV;    endosomal carrier vesicle;   

DOI  :  10.1016/S0014-5793(01)02484-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Internalization of receptors and other cell surface components is well known to occur via clathrin-mediated endocytosis, although other less well characterized pathways are also involved. Internalized receptors are then delivered to early endosomes, where they are sorted to be recycled back to the plasma membrane for reutilization or transported to late endosomes/lysosomes for degradation. Endocytosis has long been considered as a constitutive, housekeeping function of animal cells that occurs independently of the cellular environment in contrast to regulated secretion. Here, we will discuss recent studies that are uncovering the existence of cross-talk between signaling molecules and components of the transport machinery, indicating that endocytosis can be modulated by signaling pathways.

【 授权许可】

Unknown