The phosphatidylinositol 3‐phosphate‐binding FYVE finger

FEBS Letters

Aasland, Rein¹  Stenmark, Harald²  Driscoll, Paul C.³ 

[1] Department of Molecular Biology, University of Bergen, P.O. Box 7800, HiB, Thormøhlensgt. 55, N-5020 Bergen, Norway;Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway;Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK

关键词: FYVE domain;    Phosphatidylinositol 3-kinase;    Phosphoinositide;    Membrane traffic;    Signal transduction;   

DOI  :  10.1016/S0014-5793(01)03308-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.

【 授权许可】

Unknown