Mitochondrial permeability transition and oxidative stress

FEBS Letters

Castilho, Roger F.¹  Vercesi, Anibal E.¹  Kowaltowski, Alicia J.² 

[1] Departamento de Patologia Clı́nica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil;Departamento de Bioquı́mica, Instituto de Quı́mica, Universidade de São Paulo, São Paulo, SP, Brazil

关键词: Mitochondrion;    Calcium;    Reactive oxygen;    Free radical;    Thiol;    Cell death;    GPx;    glutathione peroxidase;    GSH;    glutathione;    MPT;    mitochondrial permeability transition;    Pi;    inorganic phosphate;    ROS;    reactive oxygen species;    TPx;    thioredoxin peroxidase;    TSH;    thioredoxin;   

DOI  :  10.1016/S0014-5793(01)02316-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.

【 授权许可】

Unknown