期刊论文详细信息
FEBS Letters | |
Mitochondrial permeability transition and oxidative stress | |
Castilho, Roger F.1  Vercesi, Anibal E.1  Kowaltowski, Alicia J.2  | |
[1] Departamento de Patologia Clı́nica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP 13083-970, Brazil;Departamento de Bioquı́mica, Instituto de Quı́mica, Universidade de São Paulo, São Paulo, SP, Brazil | |
关键词: Mitochondrion; Calcium; Reactive oxygen; Free radical; Thiol; Cell death; GPx; glutathione peroxidase; GSH; glutathione; MPT; mitochondrial permeability transition; Pi; inorganic phosphate; ROS; reactive oxygen species; TPx; thioredoxin peroxidase; TSH; thioredoxin; | |
DOI : 10.1016/S0014-5793(01)02316-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020310488ZK.pdf | 151KB | download |