Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain

FEBS Letters

Kowaltowski, Alicia J¹  Costa, Alexandre D.T¹  Vercesi, Anibal E¹ 

[1] Departamento de Patologia Clı́nica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 13083-970 Campinas, SP, Brazil

关键词: Reactive oxygen species;    Free radical;    Plant uncoupling mitochondrial protein;    Coenzyme Q;    Mitochondrion;   

DOI  :  10.1016/S0014-5793(98)00231-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H₂O₂ generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H₂O₂ generation. This H₂O₂ generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O₂ by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.

【 授权许可】

Unknown