Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

FEBS Letters

Brock, Thomas G¹  Peters-Golden, Marc¹ 

[1] Division of Pulmonary and Critical Care Medicine, The University of Michigan Health System, 6301 MSRB III, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0642, USA

关键词: Leukotriene;    5-Lipoxygenase;    Nucleus;    Compartmentalization;    Metabolon;    LT;    leukotriene;    5-LO;    5-lipoxygenase;    cPLA2;    cytosolic phospholipase A2;    FLAP;    5-LO activating protein;   

DOI  :  10.1016/S0014-5793(00)02374-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Leukotrienes are important lipid mediators implicated in the regulation of various cellular processes and in disease states as well as homeostasis. Regulation of leukotriene biosynthesis is therefore of considerable interest. Although the levels of expression and catalytic activity of leukotriene-forming proteins have long been recognized as important determinants of leukotriene biosynthesis, it has recently become apparent that their intracellular compartmentalization also affects the integrated output of this biosynthetic pathway. In this minireview, we focus on the unexpected discovery that the nucleus is the key intracellular site for leukotriene biosynthesis and discuss the mechanisms that regulate protein localization and the potential implications of these findings.

【 授权许可】

Unknown