Genomic Exploration of the Hemiascomycetous Yeasts: 11. Kluyveromyces lactis

FEBS Letters

Bolotin-Fukuhara, Monique¹  Lemaire, Marc⁴  Duchateau-Nguyen, Guillemette⁵  Termier, Michel⁵  Artiguenave, François³  Wésolowski-Louvel, Micheline⁴  Montrocher, Robert²  Wincker, Patrick³  Robert, Catherine³  Marmeisse, Roland²  Toffano-Nioche, Claire⁵ 

[1] Laboratoire de Génétique Moléculaire, IGM, Bâtiment 400, Centre Universitaire, 91405 Orsay, France;UMR CNRS 5557, Ecologie Microbienne, Université Claude Bernard, Bâtiment 405, 43 Bld du 11 Novembre 1918, 69622 Villeurbanne, France;Génoscope, Centre National de Séquençage, 2, rue Gaston Crémieux, P.O. Box 5706, 91057 Evry Cedex, France;Microbiologie et Génétique, ERS 2009 CNRS/UCB/INSA, Université Claude Bernard, Bâtiment 405, 43 Bld du 11 Novembre 1918, 69622 Villeurbanne, France;Laboratoire de Bioinformatique des Génomes, IGM, Bâtiment 400, Centre Universitaire, 91405 Orsay, France

关键词: Random sequencing;    Gene function;    Synteny;    Mitochondrial DNA;   

DOI  :  10.1016/S0014-5793(00)02282-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Random sequencing of the Kluyveromyces lactis genome allowed the identification of 2235–2601 open reading frames (ORFs) homologous to S. cerevisiae ORFs, 51 ORFs which were homologous to genes from other species, 64 tRNAs, the complete rDNA repeat, and a few Ty1- and Ty2-like sequences. In addition, the complete sequence of plasmid pKD1 and a large coverage of the mitochondrial genome were obtained. The global distribution into general functional categories found in Saccharomyces cerevisiae and as defined by MIPS is well conserved in K. lactis. However, detailed examination of certain subcategories revealed a small excess of genes involved in amino acid metabolism in K. lactis. The sequences are deposited at EMBL under the accession numbers AL424881–AL430960.

【 授权许可】

Unknown