Studies on the interaction between TWEAK and the death receptor WSL‐1/TRAMP (DR3)

FEBS Letters

Bodmer, Jean-Luc¹  Wang, Edward³  Kitson, Jeremy²  Jansen, Mieke²  Owen, Michael J³  Tschopp, Jurg¹  Farrow, Stuart N²  Kaptein, Allard²  Dilaver, Gonul²  Dash, Laura² 

[1] Institute of Biochemistry, University of Lausanne, Ch. Des Boveresses 155, CH-1066 Epalinges, Switzerland;Cell Biology Department, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK;Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK

关键词: TWEAK;    WSL-1;    TRAMP;    Death receptor;    Apoptosis;   

DOI  :  10.1016/S0014-5793(00)02219-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-κB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK

【 授权许可】

Unknown