A CDE/CHR tandem element regulates cell cycle‐dependent repression of cyclin B2 transcription

FEBS Letters

Brandeis, Michael¹  Berr, Frieder²  Lange-zu Dohna, Christine²  Mössner, Joachim²  Engeland, Kurt² 

[1] Department of Genetics, The Silverman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel;Medizinische Klinik II, Department of Internal Medicine, University of Leipzig, Max Bürger Research Center, Johannisallee 30, D-04103 Leipzig, Germany

关键词: Cell cycle;    CDE;    CHR;    E2F;    Transcriptional repression;    Cancer;   

DOI  :  10.1016/S0014-5793(00)02133-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cyclin B is an important regulator of progression through the cell division cycle. The oscillating appearance of cyclin B1 and B2 proteins during the cell cycle is in part due to fluctuating mRNA levels. We had identified earlier a tandem promoter element named cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) which regulates cell cycle-dependent transcription of cdc25C, cyclin A and cdc2. Here we describe that cyclin B2 transcription is repressed through a novel CDE/CHR element in resting and G₁ cells. By relief of this repression in S and G₂ oscillating expression of cyclin B2 mRNA is achieved during the cell cycle.

【 授权许可】

Unknown