Endogenous nitric oxide synthase inhibitors are responsible for the L‐arginine paradox

FEBS Letters

Bode-Böger, Stefanie M¹  Sandmann, Jörg¹  Frölich, Jürgen C¹  Böger, Rainer H¹  Tsikas, Dimitrios¹ 

[1] Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30623 Hannover, Germany

关键词: L-Arginine paradox;    Nitric oxide synthase;    Endogenous inhibitor;    Methylarginine;    Asymmetric dimethylarginine;    NO;    nitric oxide;    NOS;    nitric oxide synthase;    ADMA;    asymmetric dimethylarginine;    NMA;    (mono)methylarginine;    SDMA;    symmetric dimethylarginine;   

DOI  :  10.1016/S0014-5793(00)01686-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

L-Arginine, the substrate of nitric oxide (NO) synthases (NOSs), is found in the mammalian organism at concentrations by far exceeding K _M values of these enzymes. Therefore, additional L-arginine should not enhance NO formation. In vivo, however, increasing L-arginine concentration in plasma has been shown repeatedly to increase NO production. This phenomenon has been named the L-arginine paradox; it has found no satisfactory explanation so far. In the present work, evidence for the hypothesis that the endogenous NOS inhibitors methylarginines, asymmetric dimethylarginine being the most powerful (IC₅₀ 1.5 μM), are responsible for the L-arginine paradox is presented.

【 授权许可】

Unknown