Type I muscle atrophy caused by microgravity‐induced decrease of myocyte enhancer factor 2C (MEF2C) protein expression

FEBS Letters

Higuchi, Itsuro³  Kato, Yutaka²  Masuda, Satoko¹  Kubo, Toshikazu⁵  Kitajima, Isao¹  Yamakuchi, Munekazu¹  Maruyama, Ikuro¹  Ohira, Yoshinobu⁴ 

[1]Department of Molecular Laboratory Medicine, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

[2]Department of Microbiology and Immunology, Research Center for Infectious Disease, Aichi Medical University, Nagakute, Aichi 480-1195, Japan

[3]Department of Third Internal Medicine, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

[4]Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya City 891-23, Japan

[5]Department of Orthopedic Surgery, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan

关键词: Microgravity;    Muscle atrophy;    Differential display;    Myocyte-specific enhancer binding factor 2C;   

DOI  :  10.1016/S0014-5793(00)01715-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To investigate the molecular mechanisms of muscle atrophy under microgravity, the paraspinal muscles of rats after 14 days spaceflight and those of ground-based controls were examined. In the microgravitational environment, expressions of 42 genes changed, and the expressions of heat shock protein 70 and t complex polypeptide 1 increased. In Northern blotting, myocyte-specific enhancer binding factor 2C (MEF2C) and MEF2C-related genes including aldolase A and muscle ankyrin decreased. After 9 days ground recovery, expression of MEF2C increased and it was located mainly on the satellite cells in the muscle regeneration state. MEF2C could be a key transcriptional factor for skeletal muscle atrophy and regeneration under microgravity.

【 授权许可】

Unknown