The involvement of p38 mitogen‐activated protein kinase in the α‐melanocyte stimulating hormone (α‐MSH)‐induced melanogenic and anti‐proliferative effects in B16 murine melanoma cells

FEBS Letters

Smalley, Keiran¹  Eisen, Tim¹ 

[1] Department of Oncology, University College London, 91 Riding House Street, London W1P 8BT, UK

关键词: B16 melanoma;    p38 mitogen-activated protein kinase;    α-Melanocyte stimulating hormone;    Differentiation;    Melanocyte;   

DOI  :  10.1016/S0014-5793(00)01726-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Activation of p38 or p44/42 mitogen-activated protein (MAP) kinases has been shown to trigger differentiation in a number of cell types. The present study has investigated the roles of these kinases in the α-melanocyte stimulating hormone (α-MSH)-induced melanogenic and proliferative responses in B16 melanoma cells. Treatment of cells with α-MSH led to the time-dependent phosphorylation of both p38 and p44/42 MAP kinases. However, only inhibition of p38 MAP kinase activity with SB 203580 blocked both the α-MSH-induced melanogenic and anti-proliferative effects. It therefore appears that activation of the p38 pathway can promote melanogenesis and inhibit growth of B16 melanoma cells.

【 授权许可】

Unknown