α‐Melanocyte stimulating hormone promotes neurite outgrowth in chromaffin cells

FEBS Letters

Demeneix, Barbara¹  Grant, Nancy J.² 

[1] Institut de Physiologie Générale, CNRS UA 309, Université Louis Pasteur, 21 rue René Descartes, 67084 Strasbourg Cedex, France;INSERM U44, Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France

关键词: α-Melanocyte stimulating hormone;    Neurite;    Chromaffin cell;    Neurotrophic factor;    Neuronal plasticity;   

DOI  :  10.1016/0014-5793(88)81450-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Chromaffin cells from adult bovine adrenal medulla were found to develop neurites when cocultured with pituitary intermediate lobe (IL) cells. In coculture 51.7% of the chromaffin cells extended neurites compared with 12% in control cultures (chromaffin cells alone). A soluble factor released by IL cells was apparently involved as medium conditioned by contact with IL cells also promoted neurite outgrowth. Moreover, the addition of αMSH, one of the pro-opiomelanocortin-derived peptides secreted by IL cells, alone reproduced this effect in a dose-dependent manner. The data provide evidence for a neurotrophic role of αMSH.

【 授权许可】

Unknown