A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family

FEBS Letters

Ui-Tei, Kumiko¹  Miyata, Yuhei¹  Hamada, Tsuyoshi¹ 

[1] Department of Pharmacology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

关键词: Spinal cord-derived growth factor;    Differential display;    Chick spinal cord;    Mitogenic activity;    CUB domain;    Platelet-derived growth factor/vascular endothelial growth factor family;    SCDGF;    spinal cord-derived growth factor;    PDGF;    platelet-derived growth factor;    VEGF;    vascular endothelial growth factor;    E;    embryonic day;    TLD;    tolloid;    BMP1;    bone morphogenetic protein 1;    NP;    neuropilin;    5′-RACE;    5′-rapid amplification of cDNA ends;    EST;    expression sequence tag;    c;    chicken;    h;    human;    ORF;    open reading frame;   

DOI  :  10.1016/S0014-5793(00)01640-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.

【 授权许可】

Unknown