The PWWP domain: a potential protein–protein interaction domain in nuclear proteins influencing differentiation?

FEBS Letters

Nagl, Sylvia B.¹  den Dunnen, Johan T.²  van Ommen, Gert-Jan B.²  Stec, Ingrid² 

[1] Bloomsbury Centre for Structural Biology, Department of Biochemistry and Molecular Biology, University College London, London, UK;MGC-Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands

关键词: Protein domain;    Multiple alignment;    Protein–protein interaction;   

DOI  :  10.1016/S0014-5793(00)01449-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Upon characterization of WHSC1, a gene mapping to the Wolf–Hirschhorn syndrome critical region and at its C-terminus similar to the Drosophila ASH1/trithorax group proteins, we identified a novel protein domain designated PWWP domain. To gain insight into its structure, evolutionary conservation and its potential functional role, we performed database searches to identify other PWWP domain-containing proteins. We retrieved 39 proteins, and a multiple alignment shows that the domain spans some 70 amino acids. It is present in proteins of nuclear origin and plays a role in cell growth and differentiation. Due to its position, the composition of amino acids close to the PWWP motif and the pattern of other domains present, we hypothesize that the domain is involved in protein–protein interactions.

【 授权许可】

Unknown