Requirement of the Fas ligand‐expressing luteal immune cells for regression of corpus luteum

FEBS Letters

Suzuki, Masatoshi¹  Kuranaga, Erina¹  Takahashi, Michio¹  Furuhata, Yasufumi¹  Kanuka, Hirotaka¹  Yonezawa, Tomohiro¹  Nishihara, Masugi¹ 

[1] Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: Apoptosis;    Cell death;    Fas/Fas ligand;    Rat corpus luteum;    Luteolysis;    Luteal immune cell;   

DOI  :  10.1016/S0014-5793(00)01426-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Apoptosis in corpus luteum (CL) is induced by prolactin (PRL) in female rats. PRL-induced apoptosis in CL is mediated by the Fas/Fas ligand (FasL) system. The CL consists of steroidogenic and non-steroidogenic cells, including immunocytes. Fas mRNA was detected only in the luteal steroidogenic cells, and FasL mRNA was expressed only by the non-steroidogenic CD3-positive luteal immunocytes. Removing the luteal immune cells from the luteal cells inhibited PRL-induced luteal cell apoptosis effectively. Thus, FasL-expressing non-steroidogenic luteal immunocytes are required for PRL-induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas/FasL in CL.

【 授权许可】

Unknown