The amyloid β peptide Aβ (25–35) induces apoptosis independent of p53

FEBS Letters

Jansen-Dürr, P.¹  Blasko, I.¹  Wagner, M.¹  Whitaker, N.²  Grubeck-Loebenstein, B.¹ 

[1] Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Rennweg 10, A-6020 Innsbruck, Austria;Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Angewandte Tumorvirologie, INF 242, D-69120 Heidelberg, Germany

关键词: Alzheimer's disease;    Amyloid beta (25–35);    p53;    HPV-16 E6;    HPV-16 E7;    Apoptosis;   

DOI  :  10.1016/S0014-5793(00)01323-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Apoptosis of neuronal cells apparently plays a role in Alzheimer's disease (AD). The amyloid beta (Aβ) peptide derived from β-amyloid precursor protein is found in AD brain in vivo and can induce apoptosis in vitro. While p53 accumulates in cells of AD brain, it is not known if p53 plays an active role in Aβ-induced apoptosis. We show here that inactivation of p53 in two experimental cell lines, either by expression of the papillomavirus E6 protein or by a shift to restrictive temperature, does not affect apoptosis induction by Aβ (25–35), indicating that Aβ induces apoptosis in a p53-independent manner.

【 授权许可】

Unknown