Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitors

FEBS Letters

Thullberg, Minna²  Lukas, Jiri²  Rönnstrand, Lars¹  Bartek, Jiri²  Strauss, Michael²  Bartkova, Jirina²  Hansen, Klaus²  Khan, Selina² 

[1] Ludwig Institute for Cancer Research, Biomedical Center, S-751 24 Uppsala, Sweden;Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark

关键词: Cell cycle;    p16INK4a;    p15INK4b;    p18INK4c;    p19INK4d;    Cyclin-dependent kinases 4 and 6;   

DOI  :  10.1016/S0014-5793(00)01307-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

p16^INK4a, p15^INK4b, p18^INK4c and p19^INK4d comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.

【 授权许可】

Unknown